ED: Advanced prostate cancer doesn't know who I am. It thought I was an easy target. But it didn't know I was a fighter. It didn't know how strong I could become for my family. I didn't know how much I'd learn from the experience I had. How I would take on a more active role in my health, whether that be with my physical health or my treatment plan with my doctor. I'm Ed. My wife and I have been together just over 40 years. We live in North Carolina. We have two beautiful children. And I have my own company in commercial construction. When I was 53, everything changed. I went for a yearly physical...about two days later, the doctor himself actually called me. You know, that just never happens. Then he told me I had advanced prostate cancer. My treatment journey began with surgery and then hormone therapy to lower my testosterone. All the while, I continued to advocate for my healthcare, and during one of my doctor visits, my doctor told me about ORGOVYX.

VOICEOVER: What is ORGOVYX?

ORGOVYX (relugolix) is a prescription medicine used in adults for the treatment of advanced prostate cancer. It is not known if ORGOVYX is safe or effective in females or children.

Do not take ORGOVYX if you have had a severe allergic reaction to relugolix or any of the ingredients in ORGOVYX.

Please listen to the additional Important Safety Information within this video.

ED: So, I did some research on ORGOVYX. I was so happy to find that there was a hormone therapy option out there for me. Something that would fit into my daily routine—and it's a pill, not an injection. I was finally able to take a more active role in my treatment decision and, together with my doctor, we decided ORGOVYX was a good option for me. My doctor discussed with me the possibility of a serious side effect called long QT syndrome, a change in the electrical activity of the heart, as well as the most common side effects with ORGOVYX. After all these years of being a cancer patient, I really learned to speak up for myself and my healthcare. At this point in the journey, everything is being managed. But I am motivated in helping people understand that they need to play an active role in their healthcare. Motivation is a powerful thing, really. I'm on the verge of becoming a grandfather. That's a huge motivation. And I'm starting to realize life is to be enjoyed. One of the things I love doing is playing with my dog. It just gives me a sense of being a part of life and he's great. I go to the gym, I play golf, some piano, some guitar. I sing, I bowl, I tell a lot of dad jokes. I'm taking an active role in my life. And that's the last thing advanced prostate cancer ever expected.

VOICEOVER: Important Safety Information, continued: What should I tell my healthcare provider before taking ORGOVYX?

Tell your healthcare provider about all of your medical conditions, including if you:

• Have any heart problems, including a condition called long QT syndrome.
• Are pregnant or plan to become pregnant. ORGOVYX can harm your unborn baby and cause loss of pregnancy (miscarriage).
• Have a partner who is pregnant or may become pregnant.
  • Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with ORGOVYX and for 2 weeks after the last dose of ORGOVYX.
• Are breastfeeding or plan to breastfeed. It is not known if ORGOVYX passes into your breast milk.

Tell your healthcare provider about all the medicines or treatments you receive, including: prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking ORGOVYX with certain other medicines can affect how ORGOVYX works or may cause side effects.

You should not start or stop any medicine before you talk with your healthcare provider who prescribed ORGOVYX.

What are the possible side effects of ORGOVYX?

Serious side effects of ORGOVYX include:

• Changes in the electrical activity of your heart (QT prolongation). Your healthcare provider may check your body salts (electrolytes) and the electrical activity of your heart during treatment with ORGOVYX. Tell your healthcare provider right away if you get any signs or symptoms of QT prolongation, including:
  • dizziness
  • fainting
  • feeling that your heart is pounding or racing (palpitations)
  • chest pain
• Allergic reactions. Stop taking ORGOVYX and tell your healthcare provider or get emergency medical help right away if you get any signs or symptoms of an allergic reaction, including:
  • swelling of your face, lips, tongue, throat, or trouble swallowing
  • trouble breathing
  • hives (raised bumps), rash, or redness all over your body

Most common side effects of ORGOVYX include:

• hot flushes
• increased blood sugar levels
• increased blood fat (triglyceride) levels
• muscle and joint pain
• decreased blood hemoglobin levels
• increased liver enzymes
• tiredness
• constipation
• diarrhea

ORGOVYX may cause other side effects including weight gain, decreased sex drive, and erectile function problems.

ORGOVYX may cause fertility problems in males, which may affect your ability to father children. Talk to your healthcare provider if this is a concern for you.

These are not all the possible side effects of ORGOVYX. Call your doctor for medical advice about side effects or if you have a side effect that bothers you or does not go away.

You may report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Product Information, via the link provided.